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of the study and participated in the design of the study; QX was involved in experimental design, coordinating the experiments and manuscript preparation. All authors have read and approved the final version of the manuscrpt. XTW, FBK, CL, WYW and WL contributed equally to this article.”
“Background Glioblastoma multiforme (GBM, a grade IV glioma) is a mafosfamide primary brain tumor that is highly malignant, and the patients diagnosed with GBM remain poor prognosis despite implementation of intensive therapeutic strategies and clinical efforts. To date, the diagnosis of GBM before clinical treatment is mainly by computer tomography (CT) and nuclear magnetic resonance imaging (MRI). However, they are expensive and difficult to spread. Therefore, it is an urgent need to find new approaches to early diagnose GBM and monitor disease progress. MicroRNAs (miRNAs) are a large class of small non-coding RNAs that regulate gene expression at the post-transcriptional level [1].