The mean age at baseline was 68.0 ± 10.3 years (range 50 to 99 years); 33.6% were aged

from 45 to 64 years and 63.4% were aged 65 years or older. One hundred and seventy Caspase inhibitor subjects had died at the time of analysis and 19 patients received anti-osteoporosis CT99021 solubility dmso medication after sustaining a fracture during the follow-up period. The data for these subjects were analyzed up to their last contact time-point or time of treatment initiation. Baseline demographic information and BMD characteristics of the subjects are shown in Table 1. 7.2% of all subjects had osteoporosis with a BMD T-score ≤ −2.5 at any one site. 9.1% of men aged 65 years or above were osteoporotic compared with 4.1% in the 50- to 64-year age group. Prevalence of osteopenia (BMD T-score between −1 and −2.5 at any one site) was 47.2% in men above age 65 years and 39.2% in men aged 50 to 64 years: combined, this accounted for 44.1% of all subjects. Table 1 Baseline Demographic and BMD Characteristics of Hong Kong Southern Chinese Men (n = 1,810) PD0332991 Characteristics Mean ± SD (%) Age (year) 68 ± 10.3 Height (cm) 164.6 ± 6.5 Weight (kg) 62.9 ± 10.3 BMI (kg/m2) 28.11 ± 8.4 Grip strength

(kg) 31.6 ± 8.0 Dietary calcium intake (mg/day) 675.1 ± 282.7 History of fall within 1 year 257 (14.2%) Difficulty bending forward 185 (10.2%) Kyphosis 78 (4.3%) Low back pain 510 (28.2%) History of fragility fracture 576 (31.8%) History of clinical spine fracture and/or morphometric fracture 112 (6.2%) History of clinical spine fracture 52 (2.9%) History of parental fracture 65 (3.6%) Use of walking aid 264 (14.6%) Homebound 121 (6.7%) Walking <30 min/day 167 (9.2%) Outdoor activity <60 min/day 608 (33.6%) Current and ex-smoker 673 (37.2%) Current and ever alcohol consumption (≥3 Units/day) 43 (2.4%) Ever long term use of oral glucocorticoids 33 (1.8%) Rheumatoid arthritis 11 (0.6%) Hyperthyroidism 47 (2.6%) Hyperparathyroidism 4 (0.2%) Hypogonadism (testosterone <10 nmol/L) 257 (14.2%) No reported medical conditions 1,095 (60.5%) 1–3 reported medical

conditions 595 (32.9%) 3 or more reported medical conditions 119 (6.6%) Lumbar spine BMD (g/cm2) 0.949 ± 0.334 Lumbar spine T-score −0.4 ± 1.3 Femoral neck BMD (g/cm2) 0.697 ± 0.121 Femoral neck T-score −0.9 ± 0.8 Total hip BMD (g/cm2) 0.862 ± 0.774 Total hip T-score CYTH4 −0.7 ± 1.0 Lumbar spine BMD T-score ≤ −2.5 89 (4.9%) Femoral neck BMD T-score ≤ −2.5 58 (3.2%) Total hip BMD T-score ≤ −2.5 78 (4.3%) Osteoporosis BMD T-score ≤ −2.5 at any site 130 (7.2%) Osteopenia BMD T-score between −1 and −2.5 at any site 744 (44.1%) During the follow-up period, 37 new low-trauma fractures were reported, of which seven (22%) were clinical vertebral fractures, seven (22%) were hip fractures, two (6%) were proximal humerus fractures; nine (25%) were distal forearm fractures; and 12 (33%) were fractures at other peripheral sites.