The evident behavioral changes suggest that glutamatergic synapses directly influence
sensory, motor and emotional processes in the brain and may be especially important in the integration of environmental stimuli with emotional central state processes of animals. Considering that unresolved social loss and grief have been deemed to be among the main precipitating causes of depression, and glutamate plays a large role in the production of negative effect related to separation distress, these results are consistent with the emerging work targeting glutamate blockade as a way to produce rapid anti-depressant effects. (C) 2011 Elsevier Ltd. All rights reserved.”
“Aims:
Salmonella spp. are an important cause of Metabolism inhibitor food-borne infections throughout
world, and the availability of rapid and simple detection techniques is critical for the food industry. Salmonella enterica serovars Enteritidis and Typhimurium cause the majority of human gastroenteritis infections, and there are a reported 40 000 cases of salmonellosis in the United States each year.
Methods and Results:
A novel rapid and simple isothermal target and probe amplification (iTPA) assay that rapidly amplifies target DNA (Salmonella invA gene) using a FRET-based signal probe in an isothermal environment was developed for detection LDK378 datasheet Salmonella spp. in pre-enriched food samples. The assay was able to specifically detect all of 10 Salmonella spp. strains without detecting 40 non-Salmonella strains. The detection limit was 4 x 101 CFU per assay. The iTPA assay detected at an initial inoculum level of < 10 CFU in the pre-enriched food samples (egg yolk, chicken breast and peanut butter).
Conclusions:
This detection system requires only a water bath and a fluorometer and has great potential for use as a hand-held device or point-of-care-testing diagnostics. The iTPA assay is sensitive and specific and has potential
for rapid screening of Salmonella spp. by food industry.”
“Aims:
The objective of this study was to test a series of gossypol-related compounds for growth inhibition against Aspergillus flavus.
Methods and Results:
A series of chiral and achiral gossypol derivatives, some natural products of the cotton plant and others prepared by synthesis from gossypol, were incorporated into agar plates to follow the rate of A. flavus isolate AF13 PD0325901 cost colony growth. All tested compounds exhibited some growth inhibition against this organism. The synthetic compounds, gossypolone and apogossypolone, exhibited greater activity than either racemic or chiral gossypol. Methylated derivatives (i.e. 6-methoxy and 6,6′-dimethoxy derivatives) generally exhibited less activity than the nonmethylated parent compounds. The (-)-optical form of gossypol was found to be slightly more active than the (+)-optical form, and this trend was observed regardless of the presence of methoxy groups at the 6-position.