3). Lymph nodes showed reactive pathology. Histopathological examination of Gall bladder showed cholecystitis. Patient recovered well postoperatively without any complications and was planned for chemotherapy. Figure 1 Magnetic resonance cholangiopancreatography (MRCP) Alisertib chemical structure showing features of cholecystitis with small polyp. Figure 2 Cut section
of excised transverse Inhibitors,research,lifescience,medical colon tumor. Figure 3 Histopathological examination (H and E stain) of colon inhibitor Pfizer cancer showing tumor cells (Magnification 20×). Discussion Colorectal cancer is one of the most common cancer worldwide and its incidence is reported to be rising in developing countries, probably due to the acquisition of a western lifestyle. Colorectal cancer constitutes a major public Inhibitors,research,lifescience,medical health issue globally with an estimated 1.2 million
new cancer cases and over 630,000 cancer deaths per year, almost 8% of all cancer deaths (1,2). Globally it is the fourth most common cancer in male and the third most common in female (2). A patient with right sided colon tumor usually presents with iron deficiency anaemia, weight loss, cachexia, palpable mass and positive faecal occult blood unlike cancer from left side which causes change of bowel habit, tenesmus, fresh rectal bleeding and obstruction (3). We present a rare case of proximal transverse colon carcinoma presenting Inhibitors,research,lifescience,medical as carcinoma gall bladder. Literature also support to report a case of transverse colon cancer manifesting with Inhibitors,research,lifescience,medical signs suggestive of acute cholecystitis (4). In approximately 10% of patients, the tumor mass is usually adherent to adjacent structures (5). Structures superior to the transverse colon are less commonly involved by direct spread of
colonic tumors. The stomach, spleen and duodenum were most frequently invaded followed by diaphragm, abdominal wall, pancreas and liver (5,6). It has been shown that patients with a history of gallstone disease who subsequently had a cholecystectomy are at an increased of colorectal malignancies (7,8). The percentage of metastatic tumours in the upper gastrointestinal tract among patients with upper Inhibitors,research,lifescience,medical gastrointestinal bleeding is reported to be around 0.06% (9). Chen et al. (4) reported a case of transverse colon cancer manifesting with signs suggestive of acute cholecystitis and suggested that invasion of gall bladder resulted in an inflammatory adhesion which subsequently resulted in an acute acalculous cholecystitis Carfilzomib while Nair MS et al. (10) suggested that gall bladder empyema with colonic carcinoma most likely occurred as a result of penetration of the gallbladder wall with possible fistulation and subsequent colonic perforation and abscess formation within the gallbladder. The difference between our case and that of above mention case is that our patient had features of cholecystitis—thickened gall bladder wall with gallbladder polyp on USG suggestive of malignancy and MRCP showed cholecystitis with gall bladder polyp.