8 cm, internal diameter: 1 cm). The bolts replace the food pellets used for the same tests on monkeys. The slots were designed in a manner that chemical information subjects have to use the precision grip to retrieve the bolts, and their spatial arrangement is identical to that of the modified Brinkman board used for monkeys. In a single behavioral session, the human subjects had to execute the grasping of the 50 bolts as fast as possible, taking one bolt at a time, and putting it into a plastic box located in front of
the board in a middle position. The human subjects were #free copy keyword# not allowed to throw the bolt into the box. These rules contributed normalizing the test. The subjects performed the task 20 times, using alternatively 10 times the right hand and 10 times the left hand (right, left, right, etc.). The experimenter determined with which hand the subject had to begin (see http://www.unifr.ch/neuro/rouiller/research/PM/pm1.html Inhibitors,research,lifescience,medical [video sequences 4–5]). Bimanual Brinkman board task This task was adapted from the bimanual coordinated task of Mark and Sperry (1968). Our bimanual board is made of transparent acrylic glass (PMMA or Plexiglas®); Fig. Fig.1B).1B). The model for monkeys (Fig. (Fig.1B,1B, left panel) measures 15.8 cm long, 13.1 cm large, and has a thickness of 2 cm. It comprises nine holes. Each hole has an upper diameter of 9.5 mm and a lower diameter of 7 mm and
contains a sticky reward, like sultana or a little piece Inhibitors,research,lifescience,medical of apple. The board is fixed with an inclination of 20–30° from horizontal. The primate chair was placed in the front of the board and the two sliding doors were opened to allow access with both hands simultaneously. The monkeys had to retrieve the reward using both hands at the same time and following one or the Inhibitors,research,lifescience,medical other of two possible strategies (see below: analysis of data). One daily session included three to five repetitions of the whole board, with retrieval Inhibitors,research,lifescience,medical of each reward. Each hole represented an individual trial (see http://www.unifr.ch/neuro/rouiller/research/PM/pm1.html [video sequence
6]). The model of the bimanual board adapted for human subjects (Fig. (Fig.1B,1B, right panel) is a transparent acrylic glass board of 16 cm long, 13 cm wide, 2 cm thick, and comprising nine Batimastat holes (diameter of 2.2 cm). The board is fixed with 30° of inclination from horizontal. Before the test started, each hole was filled with a pellet in modeling clay. Using both hands, the human subjects had to take only one pellet at a time and to put it into a plastic box placed in the front of the board. In one session, the subject had to empty the board 20 times. Each hole represented an individual trial (see http://www.unifr.ch/neuro/rouiller/research/PM/pm1.html [video sequence 7]). The tube task This bimanual task was inspired by the tube task of Hopkins (1995), used to determine handedness in Chimpanzees and later in Old World monkeys (Zhao et al. 2012).