“
“Background: It has

been suggested that the etiology of cerebral microbleeds (CMBs) differs according to their location in the brain, with lobar microbleeds being caused by cerebral amyloid angiopathy and deep or infratentorial microbleeds resulting from hypertension and atherosclerosis. We hypothesized that there were associations between cerebral arterial branches, cardiovascular risk factors, and the occurrence of CMBs. We examined these relationships in the current study. Methods: Three hundred ninety-three patients with CMBs were analyzed in this study. The CMBs were listed according to the various arterial territories, and these were assessed for their relationship BMS-754807 order with cardiovascular risk factors, markers of small vessel disease, and their presence and location using multiple logistic regression. Results: Systolic blood pressure had a significant association with CMBs

in the territory of the posterior cerebral artery and the deep and infratentorial locations. The presence of lacunar infarcts, hemorrhage, and white matter changes were associated with CMBs in nearly all arterial territories. Conclusions: Hypertension increases the risk of microbleeds in the territory of the posterior cerebral artery and the deep and infratentorial locations. Cerebral amyloid angiopathy may be responsible for the microbleeds in the lobar area of brain.”
“The solid-solid crystalline transformation of isotactic polybutene-1 (iPB-1) from tetragonal form II to hexagonal form I could Cell Cycle inhibitor be accelerated by supercritical carbon dioxide (scCO(2)). In this study, in-situ Fourier transform infrared spectroscopy (FTIR) and two dimensional correlation spectroscopy (2DIR) is used to observe and investigate the crystallization behaviour of iPB in scCO(2) and compressed CO2. Based on the transform sequence given by 2DIR analysis, this transformation of helical chain structures is found to be initiated with the motion of side chains and followed

by the movement of main chains. It is speculated that the motion of polymer chains was enhanced EGFR activation with the diffusion Of CO2. Also this crystalline transition is observed even in compressed CO2, suggesting that CO2 could also diffused into polymer under high pressure near the critical pressure. This diffusion Of CO2 is indicated by the growth of IR bands being assigned to the stretching vibration of C-O. A further investigation on the mechanically heating and freely cooling of iPB provides more evidences on the process of structure transition. The result implies that the nucleus of tetragonal form 11 formed in the melt is not affected by the existence of scCO(2), but the crystallization temperature become obviously lower. (C) 2009 Elsevier Ltd. All rights reserved.