Conclusion: This method provided valid weights for seven chronic conditions. (C) 2012 Elsevier Inc. All rights reserved.”
“A concomitant one-stage unifocalization and bidirectional Glenn procedure was performed in a patient with a functionally single ventricle, pulmonary atresia, and major aortopulmonary collateral arteries (MAPCAs). Reconstruction of the absent central pulmonary artery was achieved using the MAPCAs as well

as the autologous pericardium. After 1 year, cineangiography and cardiac catheterization showed an excellent result: well-developed pulmonary arteries as well as low pressure in the superior vena cava. To the best of our knowledge, this is the first report of a successful concomitant one-stage unifocalization and bidirectional Glenn Selleckchem GDC 973 procedure.”
“Background: Mean platelet volume (MPV) could be a predictor of prognosis after ischemic stroke. Our aim is to investigate the association of MPV with a greater mortality and morbidity (defined as readmissions) after 1 year of follow-up in patients with acute stroke, and with a poor functional outcome in these

patients. Methods: Patients with ischemic stroke (N = 379) were recruited and assessed for an average of 46.27 weeks. MPV was Epigenetics inhibitor measured at admission. The sample was divided in thirds according with the tertiles of distribution of MPV. Univariate and multivariate analysis were performed. Results: The median (interquartile range) of MPV by third was 10 (0.7), 11(0.4), and 12 (0.8) fentoliters. Patients within highest third had a significant higher risk of either death or readmission (odds ratio 1.3; 95% confidence interval 1.00-1.7; P < .048) compared with patients within the lowest third. Functional outcome, defined as a modified Rankin Scale score of 3 to 6, was significantly higher (P < .0004) by greater third of MPV. Conclusions: MPV may be an easily available predictor for the prognosis in patients with acute ischemic stroke.”
“Objective: To assess the added value of multiple imputation (MI) of missing repeated outcomes measures in longitudinal data sets analyzed with linear mixed-effects (LME) models.

Study Design and

Setting: Data were used from Quisinostat a trial on the effects of Rosuvastatin on rate of change in carotid intima-media thickness (CIMT). The reference treatment effect was derived from a complete data set. Scenarios and proportions of missing values in CIMT measurements were applied and LME analyses were used before and after MI. The added value of MI, in terms of bias and precision, was assessed using the mean-squared error (MSE) of the treatment effects and coverage of the 95% confidence interval..

Results: The reference treatment effect was -0.0177 mm/y. The MSEs for LME analysis without and with MI were similar in scenarios with up to 40% missing values. Coverage was large in all scenarios and was similar for LME with and without MI.