However, since approximately 75% of all inbound travelers were

However, since approximately 75% of all inbound travelers were

Japanese, our data could mainly represent the situation of travelers’ diarrhea contracted by Japanese travelers. Using a questionnaire survey data at the Narita quarantine station, we successfully demonstrated that the risk of contracting travelers’ diarrhea is associated with age, sex, month, and destination of travel. The difference in incidence between sexes and seasonal pattern depended on the travelers’ ages. Some destinations increased the risk of contracting disease. Special attention should focus on specific subpopulations, and the AZD2014 mouse results presented here may offer potentially useful information for international travelers, clinicians, public health officials, travel agencies, and the international travel community at large. We thank Dr Masayoshi Kawai, a director of the Quarantine Station, Narita International Airport, for critical review of the manuscript. We are grateful to all quarantine officers who entered passengers’ data into the database between aircraft arrivals over the course of the study period. This work was supported in part by the Ministry of Health, Labour and Welfare through the Entrust Research Fund 18C2 (to M. H.). The authors state that they have no conflicts of interest to declare. “
“Leptospirosis belongs to the spectrum of travel-related infections. buy PLX4032 We retrospectively studied all the consecutive

cases of travel-related leptospirosis seen in our department between January 2008 and September 2011. Patients were included with a clinical picture compatible with the disease within 21 days after return, the presence of a thermoresistant antigen or IgM antibodies, Elisa ≥ 1 /400, and a positive microagglutination Rolziracetam test (MAT) ≥ 1/100. Fifteen leptospirosis cases were evaluated. Exposure occurred in Asia (47%), Africa (20%), the Caribbean (20%), and Indian Ocean (13%). Fourteen patients were infected during water-related activities. On admission the most frequent symptoms

were fever (100%), headache (80%), and digestive disorders (67%). Relevant laboratory findings included impaired liver function tests (100%), lymphocytopenia (80%), thrombocytopenia (67%), and elevated C-reactive protein (CRP) (67%). Our cases were confirmed by MAT that found antibodies against nine different serovars. Seven patients were cured with amoxicillin, four with doxycycline, two with ceftriaxone, one with ceftriaxone, doxycycline, and spiramycin, whereas one recovered spontaneously (retrospective diagnosis). Eight patients were hospitalized. All patients recovered. Our cases involved nine different serovars. They were related to travel in Asia, Africa, and the Caribbean. Bathing or other fresh-water leisure activities (canoeing, kayaking, rafting) are the most likely at-risk exposure. Any traveler with fever and at-risk exposure should be investigated for leptospirosis.

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