In contrast, 100% of patients in the post-ACCESS group had their CAL-101 molecular weight surgery during the same admission as their colonoscopy (p = 0.006). In the non-ACCESS group, three patients (19%) were discharged following inpatient colonoscopy for rectal bleeding and were operated in separate admissions within one to two weeks after their initial

admission. Table 2 Comparison of outcomes between non-ACCESS, pre-ACCESS, and post-ACCESS groups at LHSC Characteristics Non-ACCESS (n = 65) Pre-ACCESS (n = 47) Post-ACCESS (n = 37) Crenigacestat mw P Value Inpatient colonoscopy and surgery performed on same or separate admission, n(%):       0.006   Same admission 13 (20) 4 (8) 14 (38)     Separate admission 3 (5) 5 (11) 0 (0)   Median time from admission to inpatient colonoscopy, d (IQR1) 3.5 (2.4-6.9) 2 (0.9-3.6) 1.8 (1.3-3.1) 0.08 Median time from colonoscopy to OR, d (IQR1): 3.1 (0.3-8.5) 2.8 (1.0-4.0) 2.1 (1.2-2.5) 0.34   Same admission for colonoscopy and surgery 3.0 (0.14-3.6) 1.8 (0.3-4.0) 2.1 (1.2-2.5) 0.86   Separate admissions for colonoscopy and surgery 11.1 (9.0-12) 3.6 (2.8-11) 0 (0) 0.004 Median time from admission to OR, d (IQR1): 2.5 (0.93-45) 1.6 (0.8-4.6) 2.3

(1.1-4.6) 0.40   Without colonoscopy 1.4 (0.8-4.2) 1.6 (0.8-4.4) 1.5 selleck chemicals (0.7-2.8) 0.89   With colonoscopy 6.6 (4.7-11.5) 4.4 (2.7-4.8) 4.5 (3.5-5.3) 0.87 Type of operation performed, n(%):       0.96   Primary anastomosis 49 (75) 35 (74) 27 (73)     Ostomy 16 (25) 12 (26) 10 (27)   Median length of stay, d (IQR1) 13.5 (8.8-19.2) Etomidate 10.0 (6–17.2) 12 (8.5-18.5) 0.16 Status as of September 2012:       0.31   Disease-free 28 (43) 19 (40) 26 (70)     Alive with disease 11 (17) 2 (5) 6 (16)     Died of disease 18 (28) 19 (40) 3 (8)     Died of other causes 8 (12) 7 (15) 2 (6)   P values are shown for comparisons between pre- and post-ACCESS groups. 1IQR: Inter-quartile range (25%-75%). Median wait-times from admission to inpatient colonoscopy

were similar among the three groups (Table 2). Additionally, there were no differences in median wait-times from inpatient colonoscopy to surgery, if both were performed during the same admission (p = 0.86). When the inpatient colonoscopy and surgery were performed on separate admissions, however, we observed a significant difference in wait-times between the pre- and post-ACCESS groups (3.6 and 0 days respectively, p = 0.004). We did not observe any differences in hospital stay (p = 0.16), overall survival, or disease-free survival between the three groups of patients (Table 2). Discussion The emergency presentation of CRC may be considered an extreme expression of the waiting time paradox where the outcomes are poor but the “waiting time” is very short [27].