Instead of imaging and calculating the movement of a small fiducial positioned on a patient, as is commonly Site URL List 1|]# utilized [2], an APOMS can be directly attached to the patient��s head to report change Inhibitors,Modulators,Libraries in orientation without any imaging by ionizing radiation. The accelerometer sensor in the APOMS has the capability to detect sub-degree rotation in all three orthogonal directions. The number of sensors can easily be expended in order to simultaneously monitor undesired sudden orientation changes of multiple body parts. Our test results indicate that in addition to being highly accurate and sensitive, the APOMS can perform well under high energy radiation conditions.
Furthermore, while the APOMS provides sufficient signal strength for wireless communications, it does not interfere with radiation delivery.
As a final note, it must be emphasized Inhibitors,Modulators,Libraries that an APOMS is not capable of detecting and measuring any gradual linear movement. Thus, it cannot determine the actual amount of movement in the XYZ directions. Inhibitors,Modulators,Libraries Our proposed system is limited to measuring orientation and changes in orientation and detecting sudden positional changes. Inhibitors,Modulators,Libraries A more sophisticated body positioning system should be used to accurately measure movements in all six coordinates. Inhibitors,Modulators,Libraries In this experiment, however, we are only concerned with head orientation changes, since the body is typically secured during radiotherapy.The remainder of this paper is structured as follow. In Section Inhibitors,Modulators,Libraries 2, we describe a typical clinical treatment environment.
In Section 3, we elaborate on Inhibitors,Modulators,Libraries hardware description.
In Section 4, we present details of the signal processing algorithm. In Section 5, we provide a general overview of the software implementation. Finally, in Section 6, we characterize the performance of APOMS, followed by concluding remarks.2.?Clinical Treatment EnvironmentIn this Inhibitors,Modulators,Libraries section we briefly describe the general setup used in a typical Drug_discovery X-ray or radiation oncology (cancer therapy) procedure. Figure 2(a) depicts a typical brain cancer therapy treatment. The collimator, mounted on top of the gantry in the linear accelerator (linac), delivers radiation Brefeldin_A in a pre-determined pattern to the target. The APOMS consists of two parts: the wireless node (WN) and the base station (BS).
The accelerometer sensor of the wireless node is attached to the patient in the treatment room, as shown in Figure 2(a). The base station is placed in the control room for monitoring the patient��s head orientation. As shown in Figure 2(a), the control room and the treatment room are first completely isolated with a thick shielded wall. The shielding together structure has a very high attenuation factor and it is designed to prevent personnel access and limiting exposure to scattered radiation from the collimator.