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they have no competing interests. Authors’ contributions CC and AF performed these experiments. LG performed statistical study. All authors wrote, read and approved the final manuscript.”
“Background It is estimated that one-third of the world’s population is infected with M. tuberculosis and 8.7 million suffer from active TB and 1.4 million deaths occur due to it every year [1]. M. tuberculosis is able to evade the human immune response in part by triggering formation of insulating hypoxic granulomas following infection of pulmonary macrophages. Bacilli within this environment have adapted themselves to slowly replicate and respire, making them tolerant of many drugs. This resistant state is thought to contribute to the prolonged combination chemotherapy required to cure patients [2, 3]. Lack of compliance with treatments lasting up to 9 months contributes to the emergence of resistant strains [4]. To contain this situation, new anti-tuberculosis drugs and lesser duration of treatment are of immediate requirement. The discovery of new drugs involves several constraints that discourage many companies from investing in novel anti-TB drugs. The research is expensive, slow and difficult, and it requires specialized facilities for handling M. tuberculosis.