Kaplan-Meier survival analysis showed that neither EBV nor p53 expression was statistically significantly associated with event-free survival. Our data showed a low frequency of EBV association with pediatric FK228 cost T-cell lymphoma. It seems that p53

plays an important role in proliferation in our studied population, since it is overexpressed in 92% of T-cell lymphoma cases.”
“Aims Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of refractory overactive bladder syndrome (OAB). The Urgent-SQ is an implant that is surgically placed near the PTN and activated by an external pulse generator, allowing for on demand PTN stimulation, without the need for needle insertion. The current study presents results of a 9-year, open-label, follow-up of eight patients to address the long term safety and efficacy of the implant. Methods In 2003, eight patients https://www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html with refractory OAB received a Urgent-SQ implant and were systematically followed up for 1 year. After that, the follow up continued as open-label study. The seven patients who still had the implant were contacted after 9 years and evaluated with an interview, physical exam, ankle X-ray, voiding

diaries, and completed questionnaires about adverse events, performance, efficacy, safety, and quality of life (validated iQoL). Results Six of the seven patients still had sensory and loco-motor responses on stimulation

at 9-year follow-up. Three of four patients who had a successful treatment response at 1 year, still use the device. The fourth patient restarted therapy. The implants are intact with no migration and/or displacement. All patients reported easy selleck products handling of the Urgent-SQ. One patient reported sporadic spontaneous sensory responses. One patient reported occasional localized ankle discomfort. Conclusions After 9 years of clinical experience, we demonstrated that implant driven PTNS with the Urgent-SQ is a safe therapy for OAB. The implant has a long lifespan and is well tolerated by patients. Neurourol. Urodynam. 32: 472-475, 2013. (c) 2012 Wiley Periodicals, Inc.”
“Whereas the effects of chemotherapy during pregnancy for mother and fetus are well described, its effects on the placenta remain largely undetermined. We performed a retrospective clinicopathologic analysis of the placenta following chemotherapy. Charts were reviewed for type of malignancy, type and timing of chemotherapy, and fetal and pregnancy outcome. Placentas were studied by standard pathologic analysis as well as computer-assisted morphometry and fluorescence in situ hybridization (FISH) analysis. Patients (n = 13) underwent chemotherapy during pregnancy for carcinoma of breast (3), ovary (2), cervix (2), salivary gland (1), lymphoma/leukemia (4), or rhabdomyosarcoma (1).