Many thanks to Professor Miles Fisher (Consultant Physician, Glasgow Royal Infirmary) and Dr Gerry McKay (Consultant Physician, Glasgow Royal

Infirmary) for their support while writing this report. There are no conflicts of interest. “
“A 44-year-old gentleman with type 1 diabetes mellitus was found collapsed with diabetic ketoacidosis. Following correction of the metabolic derangements his level of consciousness improved but he became encephalopathic, exhibiting unprecedented aggression with non-specific neurological signs. This profound neurological find more state persisted for one month. Reversible causes of encephalopathy were investigated and excluded. The patient made a slow and almost complete recovery over a period of six months. Encephalopathy is an unusual complication of hyperglycaemic emergencies with poorly understood underlying mechanisms. This case demonstrates the importance of considering and treating the numerous reversible causes of an encephalopathic state before attributing altered levels of consciousness to the acute metabolic disturbances only. Copyright © 2010 John Wiley & Sons. “
“This

chapter contains sections titled: Embryology, anatomy and physiology of the thyroid gland Foetal and neonatal thyroid metabolism Thyroid function tests (TFTs) Definition and classification of thyroid disorders Rapamycin mw Neonatal hypothyroxinaemia, hyperthyrotropinaemia and transient neonatal hypothyroidism Congenital hypothyroidism Acquired hypothyroidism Hyperthyroidism Thyroid neoplasia Miscellaneous disorders Transition When to involve a specialist centre Future developments Controversial points Common pitfalls Significant guidelines/consensus statements Useful information

for patients and parents Case histories Further reading “
“Hypoglycaemia SPTLC1 is a common cause of presentation to emergency departments. Intentional overdose with long-acting insulin analogues is a recognised cause of hypoglycaemia; however, rates among those with insulin dependent diabetes are not well documented. Cases of intentional insulin overdose may be misdiagnosed as accidental, and therefore under-reported. This may be in part due to the narrow therapeutic index of the drug, as well as reluctance among patients to admit their intent.1 One retrospective study found that 90% of cases of insulin overdose were suicidal or parasuicidal.2 It has previously been reported that altered time effect profile occurs with massive overdose of long-acting insulin (i.e. duration of action greater than the expected 16–35 hours).3–5 The case described here is of interest because of the scale of the overdose, and the prolonged requirement for dextrose infusion. A 42-year-old man has had known type 1 diabetes since May 1997, usually maintained on a basal bolus regimen of approximately 8–18 units of NovoRapid and 30 units of glargine at night, with normal renal function.