“
“Objective: Recent studies have suggested that magnesium (Mg) ions exert a beneficial effect on implant osseointegration. This study assessed the osseointegration

of nanoporous titanium (Ti) surface incorporating the Mg produced by hydrothermal treatment in rabbit cancellous bone to determine whether this surface would further enhance bone healing of moderately rough-surfaced implants in cancellous bone, and compared the Saracatinib solubility dmso result with commercially available micro-arc oxidized Mg-incorporated implants.\n\nMaterial and methods: The Mg-incorporated Ti surfaces (RBM/Mg) were obtained by hydrothermal treatment using an alkaline Mg-containing solution on grit-blasted moderately rough (RBM) implants. Untreated RBM and recently introduced Mg-incorporated microporous Ti implants produced by microarc oxidation (M) were used controls in this study. The surface characteristics were evaluated by scanning electron microscopy, X-ray photoelectron spectroscopy and optical profilometry. Twenty-four threaded implants with a length of 10mm (eight RBM implants, eight RBM/Mg implants and eight M implants) were placed in the femoral condyles

of 12 New Zealand White rabbits. Histomorphometric analysis was performed 4 weeks after implantation.\n\nResults: Hydrothermally treated and untreated grit-blasted implants displayed almost identical surface morphologies and R-a values at the micron-scale. The RBM/Mg implants exhibited morphological differences compared with the RBM implants

at the nano-scale, which displayed nanoporous surface structures. LY2606368 clinical trial The Mg-incorporated implants (RBM/Mg and M) exhibited find more more continuous bone apposition and a higher degree of bone-to-implant contact (BIC) than the untreated RBM implants in rabbit cancellous bone. The RBM/Mg implants displayed significantly greater BIC% than untreated RBM implants, both in terms of the all threads region and the total lateral length of implants (P<0.05), but no statistical differences were found between the RBM/Mg and M implants except BIC% values in total lateral length.\n\nConclusion: These results indicate that a nanoporous Mg-incorporated surface may be effective in enhancing the osseointegration of moderately rough grit-blasted implants by increasing the degree of bone – implant contact in areas of cancellous bone.”
“Objective: This study evaluated the potential effects of short-term treatment with lisdexamfetamine dimesylate (LDX) on both subjective and objective sleep characteristics in children aged 6 to 12 years (n = 24) with ADHD. Method: Polysomnography (PSG) and actigraph measures as well as assessments of subjective sleep parameters were examined in children before and after treatment with either LDX or placebo in a randomized, double-blind, single-center, parallel-group study. Results: There was no statistically significant increase in the primary endpoint of latency to persistent sleep (LPS) for the LDX-treated group compared to the placebo group.