Objective: This is the first study conducted in India, investigating the role of PTGDR -441C/T promoter polymorphism in asthma pathogenesis.

Methods: A case-control study was performed with a total of 992 subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. The PTGDR -441C/T polymorphism was genotyped by Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).

Results: Statistical GM6001 analysis of the results between asthma cases and controls for the

PTGDR -441C/T polymorphism showed Chi(2) (chi(2)) = 0.29, OR = 0.95, 95% CI (0.70-1.15) and p = 0.599. Neither the genotypic nor the allelic frequencies observed for Selleckchem MLN4924 the PTGDR -441C/T polymorphism, were significantly associated with asthma or asthma phenotypes.

Conclusions: The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the studied North Indian population.”
“We performed molecular dynamics simulations of silicon nanostructures submitted to various stresses and temperatures. For a given stress orientation, a transition in the onset of silicon plasticity is revealed depending on the temperature and stress magnitude. At high temperature

and low stress, partial dislocation loops are nucleated in the 111 glide set planes. But at low temperature and very high stress, perfect dislocation loops are formed in the other set of 111 planes called shuffle. This result confirmed by three different classical

potentials suggests that plasticity in silicon nanostructures could be controlled by dislocation nucleation.”
“4-Nonylphenol (4-NP), bisphenol-A (BPA) and triclosan (TCS) are three industrial chemicals used widely in daily products. This study investigated 4-NP, BPA and TCS levels in urine samples of 287 children and students aged from 3 to 24 years old in Guangzhou, China. Total (free and conjugated) amounts of 4-NP, BPA and TCS in the urine samples were detected using gas Crenigacestat cell line chromatography-mass spectrometry with negative chemical ionization. The detection rates of 4-NP, BPA and TCS were 100%, 100% and 93% respectively, given the detection limits of 3.8, 0.5 and 0.9 ng/L respectively. Data for 4-NP, BPA and TCS were presented in both creatinine-adjusted (microgram per gram creatinine) and unadjusted (microgram per liter) urinary concentrations. The geometric mean (GM) concentrations of urinary 4-NP, BPA and TCS were 15.92 mu g/g creatinine (17.40 mu g/L), 2.75 mu g/g creatinine (3.00 mu g/L) and 3.55 mu g/g creatinipe (3.77 mu g/L) respectively. Multiple regression models considering age, gender, preferred drinking bottle and log-transformed creatinine were used to calculate the adjusted least square geometric mean (LSGM).