Review

ReviewPubMedCrossRef 6. Sekido Y: Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells. Cancer Sci 2010,101(1):1–6.PubMedCrossRef 7. Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons DM, Eguchi K: Targeting the Wnt signaling Selleck CB-839 pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth. selleck screening library Anticancer Res 2007,27(6B):4239–4242.PubMed 8. Shi Y, Moura U, Opitz I, Soltermann A, Rehrauer H, Thies

S, Weder W, Stahel RA, Felley-Bosco E: Role of hedgehog signaling in malignant pleural mesothelioma. Clin Cancer Res 2012,18(17):4646–4656.PubMedCrossRef 9. Varjosalo M, Taipale J: Hedgehog: functions and mechanisms. Genes Dev 2008, 22:2454–2472.PubMedCrossRef 10. Yang L, Xie G, Fan Q,

Xie J: Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010, 29:469–481.PubMedCrossRef 11. Scales SJ, de Sauvage FJ: Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009, 30:303–312.PubMedCrossRef 12. Ma X, Chen K, Huang S: Frequent activation of the Idasanutlin hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005, 26:1698–1705.PubMedCrossRef 13. Hooper JE, Scott MP: Communicating with Hedgehogs. Nat Rev Mol Cell Biol 2005, 6:306–317.PubMedCrossRef 14. Huangfu D, Anderson KV: Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 2006, 133:3–14.PubMedCrossRef 15. Osterlund T, Kogerman P: Hedgehog signalling: how to go from Smo to Ci and Gli. Trends Cell Biol 2006, 16:176–180.PubMedCrossRef 16. Ruiz i Altaba A, Sanchez P, Dahmane N: Gli and hedgehog in cancer: tumors, embryos and stem cells. Cell press Nat Rev Cancer 2002, 2:361–372.PubMedCrossRef 17. Bi X, Han X, Zhang F, He M, Zhang Y, Zhi XY, Zhao

H: Triparanol suppresses human tumor growth in vitro and in vivo. Biochem Biophys Res Commun 2012,425(3):613–618.PubMedCrossRef 18. Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS: Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem 2003,278(35):33067–33077.PubMedCrossRef Competing interests All authors have no competing financial interests. Authors’ contributions YZ carried out the statistic analysis and drafting of the manuscript. JH carried out the cell cultures and cell proliferation assays, Western blotting and drafting of the manuscript. FZ carried out the RNA extractions and Real-time RT-PCR assays, drafting and revising the manuscript. HL participated in the statistic analysis. DMJ conceived of the study and supervised the projects. BH designed the experimental approaches and coordinated the project progression. NL participated in the cell proliferation assay and the Western Blot assay. All authors read and approved the final manuscript.

Comments are closed.