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Proc Natl Acad Sci USA 1998, 95:14863–14868.CrossRefPubMed 51. Saldanha AJ: Java Treeview–extensible visualization of microarray data. Bioinformatics 2004, 20:3246–3248.CrossRefPubMed Authors’ contributions CDV contributed with construction of the regulatory network, microarray and module analysis. JAF-G contributed with the discussion for the selection of microarray PD0332991 data, performed the construction of topological modules and comparison of modular subunits. GG contributed with the analysis and interpretation of microarray data for the physiological sections. RMG-R contributed to the analysis and interpretation of the microarray data in terms of the regulatory network, elaboration of programs for data management as well as a discussion concerning the selection and processing of microarray. All authors wrote, read and approved

the final manuscript.”
“Background Aspergillus fumigatus, the most common agent of human and animal aspergillosis, is an selleck kinase inhibitor opportunistic mould responsible for various infections in receptive hosts, ranging from colonisation of the airways in patients with cystic fibrosis to severe and often fatal disseminated infections in immunocompromised patients [1]. Elucidation of the pathogenesis of these infections has been the subject of Forskolin purchase many scientific investigations over the last few years [2, 3]. It has been suggested that numerous fungal components play a role in pathogenesis, including adhesins and hydrophobins, proteases or phospholipases, catalases and superoxide dismutases or non ribosomal peptide synthases involved in the synthesis of hydroxamate-type siderophores (for a review, see reference [1]). In addition, several virulence factors have been discovered such as gliotoxin, components involved in iron and zinc acquisition or in various signalling pathways, and melanin [1]. The latter is synthesized through the dihydroxynaphtalene (DHN)-melanin pathway (Figure 1) in A. fumigatus.