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“Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase directly implicated in protecting a wide range of organisms against internal and external metabolic insults. However, the identification of SIRT1-specific DNA targets that confer such protection have remained elusive. Using

human cells, we show that SIRT1 binds to, and transcriptionally regulates, a gene locus encoding presenilin1 (PSEN1), a protein intrinsically involved in the function of the gamma-secretase protein complex. We also demonstrate that rats fed with resveratrol exhibit a significant increase in sirt1 and psen1 expression. Finally, dietary consumption of resveratrol also leads to an enhanced find more proliferative state of neuronal stem cells in the rat hippocampus. Our findings

reveal a strong link between resveratrol-dependent SIRT1 signaling and hippocampal plasticity in the mammalian brain. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Objectives. From prior studies, we know that older adults are rarely more distracted by irrelevant speech than younger adults, which is remarkable in light of the inhibitory deficit view of aging. We tested the hypothesis FOX inhibitor that older adults are more distracted by emotional irrelevant speech during a visual cognitive task than younger adults.

Methods. Forty-eight younger (mean age = 21.9 years) and 48 older individuals (mean age = 68.1 years) performed a visual counting task while being exposed to irrelevant speech consisting of random numbers intermixed with neutral, positive, or negative words. Performance in these conditions was compared with that in Elesclomol (STA-4783) a silence condition.

Results. Irrelevant speech increased counting time and decreased accuracy similarly

for younger and older adults. Furthermore, the emotional conditions did not elicit a stronger effect than the neutral condition. Finally, we found implicit memory for irrelevant speech, but its level was independent of emotional valence and age.

Discussion. We conclude that emotional irrelevant speech has no disproportionate impact on cognitive performance in older adults. This can be regarded as a challenge to the inhibitory deficit hypothesis”
“Targeting signalling molecules to ion channels can expedite regulation and assure the proper transition of changes to excitability. In the bag cell neurons of Aplysia, single-channel studies of excised patches have revealed that protein kinase C (PKC) gates a non-selective cation channel through a close, physical association. This channel drives a prolonged afterdischarge and concomitant neuropeptide secretion to provoke reproductive behaviour. However, it is not clear if PKC alters cation channel function and/or the membrane potential at the whole-cell level.