The entropy change is found to be considerably large. Neutron diffraction study indicates that below similar to 43 K the Nd5Ge3 has flat spiral ordering with wave vector K = [0, 0, +/- 1/5] (the flat spiral axis coincides with cell parameter, a). Neutron diffraction study of Pr5Ge3 suggests that the magnetic structure of Pr5Ge3 could be similar to that in Nd5Ge3. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3556920]“
“We determined how visuomotor tasks modulated gamma-oscillations on electrocorticography in epileptic patients who underwent Elafibranor epilepsy surgery. Each visual-cue consisted of either a sentence or hand gesture instructing the subject
to press or not to press the button. Regardless of the recorded hemisphere, viewing sentence and gesture cues elicited gamma-augmentation sequentially in the lateral-polar occipital and inferior occipital-temporal areas; subsequently, button-press movement elicited gamma-augmentation in the Rolandic area. The magnitudes of gamma-augmentation in the Rolandic and inferior occipital-temporal P5091 ic50 areas were larger when the hand contralateral to the recorded hemisphere was used for motor responses. A double dissociation was found in the left inferior occipital-temporal cortex in
one subject; the lateral portion had greater gamma-augmentation elicited by a sentence-cue, whereas the medial portion had greater gamma-augmentation elicited by a gesture-cue. The present study has increased our understanding of the physiology of the human visuomotor system. (C) 2010 Elsevier Inc. All rights reserved.”
“Neurodegenerative diseases termed
Tauopathies, including Alzheimer disease, are characterized by the presence of intraneuronal neurofibrillary tangles (NFTs), composed by hyperphosphorylated protein Tau. Peptidyl-prolyl cis/trans isomerase Pin1 plays a pivotal role in the regulation of Tau phosphorylation/dephosphorylation state. Indeed, Pin1 specifically recognizes pThr231-Pro232 motif of Tau, catalyzes its isomerisation and, in dependence of the cellular environment, promotes its dephosphorylation by PP2A phosphatase: in the dephosphorylated state Tau is able to exert its physiological activity, promoting microtubules polymerization. However, Pin1 activity in Tauopathies in which Tau is mutated can be harmful, because the isomerase can accelerate progression of the disease.
Taking Selleck JQ1 into account the complexity of pathways in which Pin1, under a strict regulation, exerts its biological functions, this isomerase can be consider a promising target in the improvement and design of new therapies against Tauopathies.”
“Transport properties of the intermetallic compound Dy5Si3Ge have been studied across its structural and magnetic transitions. The compound has a monoclinic crystal structure at room temperature, and orders magnetically at 74 K (T-N) and 62 K (T-C). Upon cooling it undergoes a structural transition to an orthorhombic structure near T-C.