The patients were treated with a Children and Leukemia Group B induction regimen.
Results:
Among these patients, BCR-ABL fusion oncogene was present in 43 of 78 patients (55%). A statistically significant difference in BCR-ABL-positivity within three age groups (< 20 years, 20-50 years, > 50 years) was observed (P = 0.001). The median age was significantly higher in the BCR-ABL+ group (30 vs 19 years; P = 0.001). BCR-ABL+
patients were also characterized by higher median WBC counts (96 000/mu L vs 23 000//mu L, P = 0.002). Complete remission was achieved in 74% BCR-ABL- patients and 35% BCR-ABL+ patients (P = 0.001). Only 10% of BCR-ABL- patients achieved continued complete remission (CR). None of the BCR-ABL+ patients maintained a CR further to induction therapy. With the available therapeutic Selonsertib price protocol, the presence of a BCR-ABL fusion predicted a lower survival (P = 0.001).
Conclusion:
A high prevalence of BCR-ABL gene fusion was observed that appeared as a poor prognostic factor. Identification of this genetic entity at diagnosis is crucial for understanding the nature MK-8931 Neuronal Signaling inhibitor of adult ALL and for deciding optimal treatment.”
“Background: Currently less than 15% of children under five with fever receive recommended artemisinin-combination therapy (ACT), far short
of the Roll Back Malaria target of 80%. To understand why coverage remains low, it is necessary to examine the treatment pathway from a child getting fever to receiving appropriate treatment and to identify critical blockages. This paper presents the application of such a diagnostic approach to the coverage of prompt
and effective treatment of children with fever in rural Senegal.
Methods: A two-stage cluster sample household survey was conducted in August 2008 in Tambacounda, Senegal, to investigate treatment behaviour for children under five with fever in the previous two weeks. The treatment pathway was divided in to five key steps; the proportion of all febrile drug discovery children reaching each step was calculated. Results were stratified by sector of provider (public, community, and retail). Logistic regression was used to determine predictors of treatment seeking.
Results: Overall 61.6% (188) of caretakers sought any advice or treatment and 40.3% (123) sought any treatment promptly within 48 hours. Over 70% of children taken to any provider with fever did not receive an anti-malarial. The proportion of febrile children receiving ACT within 48 hours was 6.2% (19) from any source; inclusion of correct dose and duration reduced this to 1.3%. The proportion of febrile children receiving ACT within 48 hours (not including dose & duration) was 3.0% (9) from a public provider, 3.0% (9) from a community source and 0.3% (1) from the retail sector.