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Amisulpride no competing interests. Authors’ contributions Conception and design: RS. Acquisition of data: RS, AG, MAC, FR, EL, CC, PV, JME. Statistical analysis: RS. Manuscript writing: RS, AG, FB, JME. Final approval: all authors.”
“Introduction Childhood cancer survivors exposed to anthracyclines are at increased risk for premature cardiac morbidity and mortality [1–8]. For 30 years after cancer treatment, survivors are 15 times more likely to experience heart failure than the general population [8]. Cardiac effects of the therapy for acute leukemia in childhood are of particular concern. In more than half of the exposed survivors, cardiotoxic treatment was found to be associated with left ventricular (LV) subclinical structural and functional abnormalities, which can progress to clinically manifested heart failure [9]. Diagnosis of cardiac dysfunction and heart failure after anticancer therapy is based on medical history, physical examination and is further confirmed by other tests, mainly echocardiography.