CrossRef 27. Roca-Feltrer A, Carneiro I, Smith L, Schellenberg JR, Greenwood B, Schellenberg D: The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings. Malar J 2010, 9:282.PubMedCrossRef 28. Zilversmit MM, Chase EK, Chen DS, Awadalla P, Day KP, McVean G: Hypervariable antigen genes in malaria have ancient roots. BMC Evol Biol 2013, 13:110.PubMedCrossRef 29. Barry AE, Leliwa-Sytek A, Tavul L, Imrie H, Migot-Nabias F, Brown SM, McVean GA, Day KP: Population genomics of the immune evasion (var) genes of plasmodium falciparum. PLoS pathogens 2007,3(3):e34.PubMedCrossRef 30. Angeletti SB431542 order D, Albrecht L, Blomqvist K, Quintana Mdel P, Akhter
SM, Sawyer A, Sandalova T, Achour A, Wahlgren M, et al.: Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1alpha. PLoS One 2012,7(12):e50758.PubMedCrossRef 31. Albrecht SB202190 in vivo L, Moll K, Blomqvist K, Normark J, Chen Q, Wahlgren M: var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive plasmodium falciparum clone FCR3S1.2. Malar J 2011, 10:17.PubMedCrossRef 32. Fawcett T: ROC Graphs: Notes and Practical Go6983 Considerations for Researchers. Netherlands: Kluwer Academic Publishers; 2004. 33. Duffy PE, Sahu T, Akue A, Milman N, Anderson C: Pre-erythrocytic malaria vaccines: identifying the targets. Expert Rev Vaccines 2012,11(10):1261–1280.PubMedCrossRef 34. Artzy-Randrup Y, Rorick MM, Day K, Chen D, Dobson AP, Pascual M: Population structuring of multi-copy, antigen-encoding genes in plasmodium falciparum. eLife 2012, 1:e00093.PubMedCrossRef Competing interests The authors declare no competing interests. Authors’ contributions MMR conceived of the study, carried out the analysis and wrote the of manuscript.
KPD, MP and TSR contributed to the study design and critically revised the manuscript. EBB contributed to the data analysis and critically revised the manuscript. All authors read and approved the final manuscript.”
“Background Hyaluronic acid (HA), a large linear glycosaminoglycan which is mostly present within extracellular matrix and whose molecular weight ranges from 8 × 105 (LMWHA) to 2 × 106 (HMWHA) Da , is a chain of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine . HA is involved in biological and pathological processes such as cell adhesion, migration, proliferation, differentiation , vascular diseases and lymphocyte trafficking [4, 5]. HA Anti-inflammatory action [6, 7], bacteriostatic effect  and antioxidant properties  have been recently highlighted with a wide range of potential therapeutic perspectives such as oral, pneumological, dermatological and urological areas . Healing properties of degradation products of HA achieved by N-acetylglucosaminic bonds breakdown, catalysed by the hyaluronidases, have been also well described in the literature .